PUBLICATIONS
2024
108: Garrett Muir, Ian Paterson, Nelson Y. S. Lam, Robert Britton. 'Synthesis of the Phormidolide A Macrocycle Supports the Proposed Configurational Reassignment' Organic Letters, 2024
107: Xiaocen Lu, Luiz F. M. Passalacqua, Matthew Nodwell, Kristen Y. S. Kong, Guillermo Caballero-García, Elena V. Dolgosheina, Adrian R. Ferré-D'Amaré, Robert Britton, Peter J. Unrau. 'Symmetry breaking of fluorophore binding to a G-quadruplex generates an RNA aptamer with picomolar KD' Nucleic Acids Research, 2024
*NAR Breakthrough Article
106: Pierre-André Gilormini, V. Narasimharao Thota, Anthony Fers-Lidou, Roger A. Ashmus, Matthew Nodwell, Jacob Brockerman, Chu-Wei Kuo, Yang Wang, Taylor E. Gray, Nitin, Anthony W. McDonagh, Shih-Yun Guu, Nursah Ertunc, Dominick Yeo, Wesley F. Zandberg, Kay-Hooi Khoo, Robert Britton, and David J. Vocadlo. 'A metabolic inhibitor blocks cellular fucosylation and enables production of afucosylated antibodies' Proceedings of the National Academy of Sciences, 2024
105: Darryl M. Wilson. Daniel J. Driedger, Dennis Y. Liu, Sandra Keerthisinghe, Adrian Hermann, Christoph Bieniossek, Roger G. Linington and Robert Britton. 'Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides' Nature Communications, 2024
104: Darryl M. Wilson and Robert Britton. 'Enantioselective Total Synthesis of the Marine Macrolides Salarins A and C' Journal of the American Chemical Society, 2024
103: Gokce Engudar, Zheliang Yuan, Matthew B. Nodwell, Hua Yang, Chelsey Currie, Stuart McDiarmid, Robert Britton & Paul Schaffer. 'Design and implementation of an automated DT-PhotoFluor radiosynthesis module for 18F-fluorination of aliphatic, branched chain amino acids' Journal of Flow Chemistry, 2024
102: Felix Gruber, Dr. Anthony W. McDonagh, Victoria Rose, Dr. James Hunter, Dr. Laura Guasch, Dr. Rainer E. Martin, Dr. Stefanie N. Geigle, Prof., and Dr. Robert Britton. 'sp3-Rich Heterocycle Synthesis on DNA: Application to DNA-Encoded Library Production' Angewandte Chemie International Edition, 2024
2023
101: Zheliang Yuan and Robert Britton. 'Development and application of decatungstate catalyzed C–H 18F- and 19F-fluorination, fluoroalkylation and beyond' Chemical Science, 2023
100: Roger A. Ashmus, Yang Wang, Manuel González-Cuesta, Dustin T. King, Ben Tiet, Xi Chen, Yanping Zhu, Bryce Kirk, José M. García Fernandez, Carmen Ortiz Mellet, Robert Britton and David J Vocadlo. 'Potent and Selective Cell-Active Iminosugar Inhibitors of Human α-N-Acetylgalactosaminidase (α-NAGAL)' Chemistry - A European Journal, 2023
99: Cohan Huxley, Callum Lucas, Juan Manuel Mesa Bruno, Matthew J. Anketell, Emma K. Davison, Garrett Muir, Matthew B. Nodwell, Michael Meanwell, Steven M. Silverman, Robert Britton and Louis-Charles Campeau. 'Efficient protocol for the preparation of α-heteroaryl acetaldehydes' Canadian Journal of Chemistry, 2023
98: Anissa Kaghad, Dimitrios Panagopoulos, Guillermo Caballero-García, Huimin Zhai and Robert Britton. 'An α-chloroaldehyde-based formal synthesis of eribulin' Nature Communications, 2023
2022
97. Josiah J. Newton, Gökçe Engüdar, Alan J. Brooke, Holly Horngren-Rhodes, Rainer E. Martin, Paul Schaffer, Robert Britton and Chadron M. Friesen. 'Rapid 18F- and 19F-Difluoromethylation through Desulfurative Fluorination of Transient N-, O-, and C-Linked Dithioles' Chemistry - A European Journal, 2022
96. Oluwafemi Akintola, Marco Farren-Dai, Weiwu Ren, Sandeep Bhosale, Robert Britton, Katarzyna Świderek, Vicent Moliner and Andrew J. Bennet. 'Glycoside Hydrolase Catalysis: Do Substrates and Mechanism-Based Covalent Inhibitors React via Matching Transition States?' ACS Catalysis, 2022
95. Andreas Fischer, Regine Gries, Santosh K. Alamsetti, Emmanuel Hung, Andrea C. Roman Torres, Yasasi Fernando, Sanam Meraj, Weiwu Ren, Robert Britton and Gerhard Gries. 'Origin, structure and functional transition of sex pheromone components in a false widow spider.' Communications Biology, 2022
94. R. Gries, G. Khaskin, P. Cepeda, G. Gries, R. Britton and J.H. Borden. 'Attractive host kairomones for the cigarette beetle, Lasioderma serricorne (Coleoptera: Anobiidae)' Journal of Stored Products Research, 2022
93. Emma K. Davison, David A. Petrone, Michael Meanwell, Matthew B. Nodwell, Steven M. Silverman, Louis Charles Campeau and Robert Britton. 'Practical and concise synthesis of nucleoside analogs' Nature Protocols, 2022
92. Samy Cecioni, Roger A. Ashmus, Pierre André Gilormini, Sha Zhu, Xi Chen, Xiaoyang Shan, Christina Gros, Matthew C. Deen, Yang Wang, Robert Britton and David J. Vocadlo. 'Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates' Nature Chemical Biology, 2022
91. Zhegao Ye, Ziran Lei, Xiaodong Ye, Liejin Zhou, Yanan Wang, Zheliang Yuan, Feng Gao and Robert Britton. 'Decatungstate Catalyzed Synthesis of Trifluoromethylthioesters from Aldehydes via a Radical Process' Journal of Organic Chemistry, 2022
2021
90. Robert Britton, Veronique Gouverneur, Jin-Hong Lin, Michael Meanwell, Chuanfa Ni, Gabriele Pupo, Ji-Chang Xiao and Jinbo Hu. 'Contemporary Synthetic Strategies in Organofluorine Chemistry' Nature Reviews Methods Primers, 2021
89. Michael Meanwell, Gaelen Fehr, Weiwu Ren, Bharanishashank Adluri, Victoria Rose, Johannes Lehmann, Steven M. Silverman, Rozhin Rowshanpour, Christopher Adamson, Milan Bergeron-Brlek, Hayden Foy, Venugopal Rao Challa, Louis-Charles Campeau, Travis Dudding and Robert Britton. 'Diversity-oriented Synthesis of Glycomimetics' Communications Chemistry, 2021
88. Roger A. Ashmus, Yang Wang, Manuel González-Cuesta, Dustin T. King, Ben Tiet, Pierre-André Gilormini, José M. García Fernández, Carmen Ortiz Mellet, Robert Britton and David J. Vocadlo. 'Rational design of cell active C2-modified DGJ analogues for the inhibition of human α-galactosidase A (GALA)' Organic and Biomolecular Chemistry, 2021
87. Han Zhang, Qing Wang, Yanan Wang, Zheliang Yuan, Feng Gao and Robert Britton. 'Selective Trifluoromethylthiolation of Unactivated C(sp3)−H Bonds Enabled by Excited Ketones' Asian Journal of Organic Chemistry, 2021
86. Oluwafemi Akintola, Weiwu Ren, Pal John Pal Adabala, Sandeep Bhosale, Yang Wang, Yumeela Ganga-Sah, Robert Britton and Andrew J. Bennet. 'Intrinsic Nucleophilicity of Inverting and Retaining Glycoside Hydrolases Revealed Using Carbasugar Glyco-tools' ACS Catalysis, 2021
85. Asim Renyard, Regine Gries, Jan Lee, Jaime M. Chalissery, Sebastian Damin, Robert Britton and Gerhard Gries. 'All Sugars Ain't Sweet: Selection of Particular Mono-, Di- and Trisaccharides by Western Carpenter Ants and European Fire Ants' Royal Society Open Science, 2021
84. Venugopal Rao Challa, Daniel Kwon, Matthew Taron, Hope Fan, Baldip Kang, Darryl Wilson, F. P. Jake Haeckl, Sandra Keerthisinghe, Roger G. Linington and Robert Britton. 'Total Synthesis of Biselide A' Chemical Science, 2021
83. Vijayaratnam Santhakumar, Mathew Sutherland, Alice Li, Anissa Kaghad, Dimitrios Panagopoulos, Fengling Li, Magdalena Szewczyk, David Smil, Cora Scholten, Léa Bouché, Timo Stellfeld, Cheryl H. Arrowsmith, Dalia Barsyte, Masoud Vedadi, Ingo V. Hartung, Holger Steuber and Robert Britton. 'Rational Design and Synthesis of Selective PRMT4 Inhibitors: a New Chemotype for Development of Cancer Therapeutics' ChemMedChem, 2021
82. Matthew B. Nodwell and Robert Britton. 'Enterobactin on a Bead: Parallel, Solid Phase Siderophore Synthesis Reveals Structure-Activity Relationships for Iron Uptake in Bacteria' ACS Infectious Diseases, 2021
2020
81. Josiah J. Newton, Alan J. Brooke, Bastian Duhamel, Jason M. Pulfer, Robert Britton and Chadron M. Friesen. 'Fluorodesulfurization of Thionobenzodioxoles with Silver (I) Fluoride' Journal of Organic Chemistry, 2020
80. Weiwu Ren, Marco Farren-Dai, Natalia Sannikova, Katarzyna Świderek, Yang Świderek, Oluwafemi Akintola, Robert Britton, Vicent Moliner and Andrew J. Bennet. 'Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design' Chemical Science, 2020
79. Michael Meanwell, Steven M. Silverman, Johannes Lehmann, Bharanishashank Adluri, Yang Wang, Ryan Cohen, Louis-Charles Campeau and Robert Britton. 'A Short de novo Synthesis of Nucleoside Analogs' Science, 2020
78. Ikenna E. Ndukwe, Xiao Wang, Nelson Y.S. Lam, Kristaps Ermanis, Kelsey L. Alexander, Matthew J. Bertin, Gary E. Martin, Garrett Muir, Ian Paterson, Robert Britton, Jonathan M. Goodman, Eric J.N. Helfrich, Jörn Piel, William H. Gerwick, R. Thomas Williamson. 'Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A' Chemical Communications, 2020
77. Josiah J. Newton, Benson J. Jelier, Michael Meanwell, Rainer E. Martin, Robert Britton and Chadron M. Friesen. 'Quaternary Ammonium Trifluoromethoxide Salts as Stable Sources of Nucleophilic OCF3' Organic Letters, 2020
2019
76. Josiah Newton, Daniel Driedger, Dr. Matthew B. Nodwell, Dr. Paul Schaffer, Dr. Rainer E. Martin, Prof. Dr. Robert Britton and Prof. Dr. Chadron M. Friesen. 'A Convenient Synthesis of Difluoroalkyl Ethers from Thionoesters using Silver (I) Fluoride' Chemistry - A European Journal, 2019
75. Zheliang Yuan, Hua Yang, Noeen Malik, Milena Colovic, David S. Weber, Darryl Wilson, Francois Benard, Rainer E. Martin, Jeffrey J. Warren, Paul Schaffer and Robert Britton. 'Electrostatic Effects Accelerate Decatungstate-catalyzed C-H Fluorination using [18]F- and [19F]NFSI in Small Molecules and Peptide Mimics' ACS Catalysis, 2019
74. Nelson Y.S. Lam, Garrett Muir, Venugopal Rao Challa, Robert Britton and Ian Patterson. 'A Counterintuitive Stereochemical Outcome from a Chelation-controlled Vinylmetal Aldehyde Addition Leads to the Configurational Reassignment of Phormidolide A' Chemical Communications, 2019
73. Weiwu Ren, Regine Gries, Kenji L. Kurita, Catherine S. McCaughey, Santosh K. Alamsetti, Roger G. Linington, Gerhard Gries and Robert Britton. 'Isolation, Structure Elucidation, and Total Synthesis of Dolichovespulide, a Sesquiterpene from Dolichovespula Yellowjackets' Journal of Natural Products, 2019
72. Matthew B. Nodwell, Hua Yang, Helen Merkens, Noeen Malik, Milena Colovic, Bjoern Wagner, Rainer E. Martin, Francois Benard, Paul Schaffer and Robert Britton. '18F-branched chain amino acids: structure-activity relationships and PET imaging potential' The Journal of Nuclear Medicine, 2019
2018
71. Josiah J. Newton, Robert Britton and Chadron M. Friesen. 'Base-Catalyzed Transesterification of Thionoesters' The Journal of Organic Chemistry, 2018
70. Weiwu Ren, Robert Pengelly, Marco Farren-Dai, Saeideh Shamsi Kazam Abadi, Verena Oehler, Oluwafemi Akintola, Jason Draper, Michael Meanwell, Saswati Chakladar, Katarzyna Swiderek, Vicent Moliner, Robert Britton, Tracey M. Gloster & Andrew J. Bennet. 'Revealing the Mechanism for Covalent Inhibition of Glycoside Hydrolases by Carbasugars at an Atomic Level' Nature Communications, 2018
69. Michael Meanwell, Johannes Lehmann, Marc Eichenberger, Rainer E. Martin and Robert Britton. 'Synthesis of Acyl Fluorides via Photocatalytic Fluorination of Aldehydic C-H Bonds' Chemical Communications, 2018
68. Dr. Zheliang Yuan, Dr. Matthew B. Nodwell, Dr. Hua Yang, Dr. Noeen Malik, Helen Merkens, Dr. Francois Benard, Dr. Rainer E. Martin, Dr. Paul Schaffer, Professor Robert Britton. 'Site-Selective, Late-Stage C-H 18F-Fluorination on Unprotected Peptides for Positron Emission Tomography Imaging' Angewandte Chemie International Edition, 2018
67. Weiwu Ren, Regine Gries, Catherine McCaughey, Nathan Derstine, Santosh K. Alamsetti, Kenji L. Kurita, Lorna Tu, Professor Roger G. Linington, Professor Robert Britton and Professor Gerhard Gries. 'Maculatic Acids - Sex Attractant Pheromone Components of Bald-Face Hornets' Angewandte Chemie International Edition, 2018
* Selected for the Front Cover of Journal
66. Regine Gries, Huimin Zhai, Andrew R. Lewis, Robert Britton and Gerhard Gries. 'Common bed bugs can biosynthesize pheromone components from amino acid precursors in human blood' Canadian Journal of Chemistry, 2018
65. Michael Meanwell, Bharani Shasank Adluri, Zheliang Yuan, Josiah Newton, Philippe Prevost, Matthew B. Nodwell, Chadron M. Friesen, Paul Schaffer, Rainer E. Martin and Robert Britton. 'Direct Heterobenzylic Fluorination, Difluorination and Trifluoromethylthiolation with Dibenzenesulfonamide Derivatives' Chemical Science, 2018
64. Michael Meanwell and Robert Britton. 'Synthesis of Heterobenzylic Fluorides' Synthesis, 2018
2017
63. Michael Meanwell, Mathew Sutherland and Robert Britton. 'Application of Sequential Proline-catalyzed α-chlorination and Aldol Reactions in the Total Synthesis of 1-deoxygalactonojirimycin' Canadian Journal of Chemistry, 2017
62. Christian Roth, Sherry Chan, Wendy Offen, Glyn Hemsworth, Lianne Willems, Dustin King, Dr. Vimal Varghese, Prof. Robert Britton, Prof. David Vocadlo and Prof. Gideon Davies. 'Structural and Functional Insight into Human O-GlcNAcase' Nature Chemical Biology, 2017
61. Dr. Matthew Nodwell, Hua Yang, Milena Colovic, Dr. Zheliang Yuan, Helen Merkens, Dr. Martin Reiner, Francois Benard, Dr. Paul Schaffer and Prof. Robert Britton. '18F-Fluorination of Unactivated C-H Bonds in Branched Aliphatic Amino Acids: Direct Synthesis of Oncological Positron Emission Tomography Imaging Agents' Journal of the American Chemical Society, 2017
2016
60. Dr. Stanley Chang, Dr. Michael Holmes, Dr. Jeffrey Mowat, Michael Meanwell and Prof. Robert Britton. 'a-Arylation and Ring Expansion of Annulated Cyclobutanones: Stereoselective Synthesis of Functionalized Tetralones' Angewandte Chemie International Edition, 2016
59. Christopher Adamson, Robert J. Pengelly, Saeideh Shamsi Kazem Abadi, Dr. Saswati Chakladar, Jason Draper, Prof. Robert Britton, Dr. Tracey M. Gloster and Prof. Andrew J. Bennet. 'Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars' Angewandte Chemie, International Edition, 2016
* Selected as a "Very Important Paper"
58. Rainer E. Martin, Johannes Lehmann, Thibault Alzieu, Mario Lenz, Marjorie A. Carnero Corrales, Johannes D. Aebi, Hans Peter Marki, Bernd Kuhn, Kurt Amrein, Alexander V. Mayweg and Robert Britton. 'Synthesis of Annulated Pyridines as Inhibitors of Aldosterone Synthase (CYP11B2)' Organic and Biomolecular Chemistry, 2016
* Selected as a "Hot Article"
57. Michael Meanwell, Matthew B. Nodwell, Rainer E. Martin and Robert Britton. 'A Convenient Late-Stage Fluorination of Pyridylic C−H Bonds with N-Fluorobenzenesulfonimide' Angewandte Chemie, International Edition, 2016
56. Huimin Zhai, Michael Hrabar, Regine Gries, Gerhard Gries and Robert Britton. 'Total Synthesis, Stereochemical Assignment, and Field-Testing of the Sex Pheromone of the Strepsipteran Xenos peckii' Chemistry - A European Journal, 2016
* Selected for the Back Cover of Journal
2015
55. Milan Bergeron-Brlek, Jake Goodwin-Tindall, Nevena Cekic, Christian Roth, Wesley F. Zandberg, Xiaoyang Shan, Vimal Varghese, Sherry Chan, Gideon J. Davies, David J. Vocadlo and Robert Britton. 'A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain-Permeable OGA Inhibitors' Angewandte Chemie International Edition, 2015
54. Shira D. Halperin, Daniel Kwon, Michael Holmes, Erik L. Regalado, Louis-Charles Campeau, Daniel A. DiRocco and Robert Britton. 'Development of a Direct Photocatalytic C-H Fluorination for the Preparative Synthesis of Odanacatib' Organic Letters, 2015
53. Stanley Chang, Soo Hur and Robert Britton. 'Total Synthesis and Configurational Assignment of Ascospiroketal A' Chemistry - A European Journal, 2015
52. Michael Hrabar, Huimin Zhai, Regine Gries, Paul W. Schaefer, Jason Draper, Robert Britton and Gerhard Gries. '(7E,11E)-3,5,9,11-Tetramethyltridecadienal: Sex Pheromone of the Strepsipteran Xenos peckii' Journal of Chemical Ecology, 2015
51. Michael Holmes, Daniel Kwon, Matthew Taron and Robert Britton. 'Total Synthesis of Amphirionin-4' Organic Letters, 2015
50. Matthew B. Nodwell, Abhimanyu Bagai, Shira D. Halperin, Rainer E. Martin, Henner Knust and Robert Britton. 'Direct photocatalytic fluorination of benzylic C-H bonds with N-fluorobenzenesulfonimide' Chemical Communications, 2015
49. Milan Bergeron-Brlek, Michael Meanwell and Robert Britton. 'Direct synthesis of imino-C-nucleoside analogues and other biologically active iminosugars' Nature Communications, 2015
48. Regine Gries, Robert Britton, Michael Holmes, Huimin Zhai, Jason Draper and Gerhard Gries. 'Bed Bug Aggregation Pheromone Finally Identified' Angewandte Chemie International Edition, 2015
47. Stanley Chang, Soo Hur and Robert Britton. 'Total Synthesis of Ascospiroketal A Through a Ag(I)-Promoted Cyclization Cascade' Angewandte Chemie International Edition, 2015
2014
46. Shira D. Halperin, Hope Fan, Stanley Chang, Rainer E. Martin and Robert Britton. 'A Convenient Photocatalytic Fluorination of Unactivated C-H Bonds' Angewandte Chemie International Edition, 2014
45. Thibaut Alzieu, Johannes Lehmann, Ajay B. Naidu, Rainer E. Martin and Robert Britton. 'Converting Oxazoles Into Imidazoles: New Opportunities for Diversity-oriented Synthesis' Chemical Communications, 2014
2013
44. Zena Qadoumi, James Senior, Milan Bergeron-Brlek and Robert Britton. 'Direct Access to Iminosugars through an Interrupted Kondrat'eva Reaction' Synlett, 2013
43. Michael T. Holmes and Robert Britton. 'Total Synthesis and Structural Revision of Laurefurenynes A and B' Chemistry - A European Journal, 2013
42. Vijay Dhand, Stanley Chang and Robert Britton. 'Total Synthesis of the Cytotoxic Anhydrophytosphingosine Pachastrissamine (Jaspine B)' Journal of Organic Chemistry, 2013
41. Milan Bergeron-Brlek, Timothy Teoh and Robert Britton. 'A Tandem Organocatalytic a-Chlorination-Aldol Reaction That Proceeds with Dynamic Kinetic Resolution: A Powerful Tool for Carbohydrate Synthesis' Organic Letters, 2013
40. Johannes Lehmann, Thibaut Alzieu, Rainer E. Martin and Robert Britton. 'The Kondrat'eva Reaction in Flow: Direct Access to Annulated Pyridines' Organic Letters, 2013
39. Stanley Chang, Saheena Desai, Daniel B. Leznoff, Nabyl Merbouh and Robert Britton. 'A Short, Gram-Scale Synthesis of 2,5-Disubstituted Furans' European Journal of Organic Chemistry, 2013
38. Vijay Dhand, Jason A. Draper, Jarod Moore and Robert Britton. 'A Short, Organocatalytic Formal Synthesis of (-)-Swainsonine and Related Alkaloids' Organic Letters, 2013
37. Shira Halperin and Robert Britton. 'Chlorine, an atom economical auxiliary for asymmetric aldol reactions' Organic and Biomolecular Chemistry, 2013
36. Jeffrey Mowat, James Senior, Baldip Kang and Robert Britton. 'Scalable Synthesis of the Pink Gypsy Moth Lymantria mathura Sex Pheromone (-)-Mathuralure' Canadian Journal of Chemistry, 2013
35. Robert Britton and Baldip Kang. 'α-Haloaldehydes: versatile building blocks for natural product synthesis' Natural Product Reports, 2013
2012
34. Stanley Chang and Robert Britton. 'Enantioselective Synthesis of Spiroacetals via Silver(I)-Promoted Alkylation of Hemiacetals: Total Synthesis of Cephalosporolides E and F' Organic Letters, 2012
33. Johannes Lehmann, Mario Lenz, Robert Britton and Rainer E. Martin. 'Synthesis of Annulated Pyridines from Oxazoles in Flow' Roche Letters (an internal, peer-reviewed company publication), November, 2012
32. Philipp Zerbe, Angela Chiang, Macaire Yuen, Björn Hamberger, Britta Hamberger, Jason A. Draper, Robert Britton and Jörg Bohlmann. 'Bifunctional cis-Abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production' Journal of Biological Chemistry, 2012
2011
31. Inhee Cho, Labros Meimetis, Lee Belding , Michael J. Katz, Travis Dudding and Robert Britton. 'Sequential Directed ortho Metalations of Hydrobenzoin: Rapid Access to Hydrobenzoin Analogues Useful for Asymmetric Synthesis' Beilstein Journal of Organic Chemistry, 2011
30. Shira Halperin, Baldip Kang and Robert Britton. 'Lithium Aldol Reactions of α-Chloroaldehydes Provide Versatile Building Blocks for Natural Product Synthesis' Synthesis, 2011
2010
29. Jason Draper and Robert Britton. 'A Concise and Stereoselective Synthesis of Hydroxypyrrolidines: Rapid Synthesis of Preussin' Organic Letters, 2010
28. Francis Gosselin, Robert A. Britton, Ian W. Davies, Sarah J. Dolman, Danny Gauvreau, R. Scott Hoerrner, Gregory Hughes, Jacob Janey, Stephen Lau, Carmela Molinaro, Christian Nadeau, Paul D. O'Shea, Michael Palucki and Rick Sidler. 'A Practical Synthesis of 5-Lipoxygenase Inhibitor MK-0633' Journal of Organic Chemistry, 2010
27. Baldip Kang, Stanley Chang, Shannon Dekker and Robert Britton. 'Regioselective and Stereoselective Cyclizations of Chloropolyols in Water: Rapid Synthesis of Hydroxytetrahydrofurans' Organic Letters, 2010
2009
26. Inhee Cho, Labros Meimetis and Robert Britton. 'Bidirectional Metalation of Hydrobenzoin: Direct Access to New Chiral Ligands and Auxiliaries' Organic Letters, 2009
25. Jeffrey Mowat, Baldip Kang, Brendan Fonovic, Travis Dudding and Robert Britton. 'Inverse Temperature Dependence in the Diastereoselective Addition of Grignard Reagents to a Tetrahydrofurfural' Organic Letters, 2009
24. Baldip Kang, Jeffrey Mowat, Thomas Pinter and Robert Britton. 'Development of a Concise and General Enantioselective Approach to 2,5-Disubstituted-3-hydroxytetrahydrofurans.' Organic Letters, 2009
23. Jeffrey Mowat, Regine Gries, Gerhard Gries, Grigori Khaskin and Robert Britton. '(S)-2-Pentyl (R)-3-Hydroxyhexanoate, a Banana Volatile and Its Olfactory Recognition by the Common Fruit Fly, Drosophila melanogaster' Journal of Natural Products, 2009
22. Robert Britton, Grigori Khaskin and Gerhard Gries. 'A chromatography-free synthesis of (2S,12Z)-2-acetoxy-12-heptadecene - The major sex pheromone component of the pistachio twig borer moth (Kermania pistaciella)' Canadian Journal of Chemistry, 2009
2007
21. Baldip Kang and Robert Britton. 'A General Method for the Synthesis of Nonracemic trans-Epoxides: Concise Syntheses of trans-Epoxide-Containing Insect Sex Pheromones' Organic Letters, 2007
20. Francis Gosselin, Robert Britton, Jeffery Mowat, Paul O'Shea and Ian Davies. 'Asymmetric Organozincate Additions to Ethyl 2,2,2-Trifluoropyruvate.' Synlett, 2007
2006
19. Regine Gries, Grigori Khaskin, Hassan Daroogheh, Cafer Mart, Serpil Karadag, Mehmet Kubilay, Robert Britton and Gerhard Gries. '(2S,12Z)-2-acetoxy-12-heptadecene: Major sex pheromone component of the pistachio twig borer moth (Kermania pistaciella) Journal of Chemical Ecology, 2006
Post-doctoral Publications
18. Ian Paterson, Robert Britton, Oscar Delgado, Nicola M. Gardner, Arndt Meyer, Guy J. Naylor and Karine G. Poullennec. 'Total Synthesis Of (-)-Dictyostatin, A Microtubule-Stabilising Anticancer Macrolide Of Marine Sponge Origin.' Tetrahedron, 2010
17. Ian Paterson, Kate Ashton, Robert Britton, Guiseppe Cecere, Gaelle Chouraqui, Gordon J. Florence, Henner Knust and Jonathon Stafford. 'Total Synthesis of (-)-Reidispongiolide A: an Actin-Targeting Macrolide Isolated from the Marine Sponge Reidispongia coerulea' Chemistry - An Asian Journal, 2008
16. Ian Paterson, Kate Ashton, Robert Britton, Guiseppe Cecere, Gaelle Chouraqui, Gordon J. Florence, and Jonathon Stafford. 'Total Synthesis of Reidispongiolide A, an Actin-Targeting Marine Macrolide.' Angewandte Chemie International Edition, 2007
15. Ian Paterson, Dirk Menche, Robert Britton, Anders E. Hakansson and Maria A. Silvia-Martinez. 'Conformational studies and solution structure of laulimalide and simplified analogues using NMR spectroscopy and molecular modelling' Tetrahedron Letters, 2005
14. Ian Paterson, Robert Britton, Oscar Delgado, Arndt Meyer and Karine G. Poullennec. 'Total Synthesis and Configurational Assignment of (-)-Dictyostatin, a Microtubule-Stabilizing Macrolide of Marine Sponge Origin.' Angewandte Chemie International Edition, 2004
Cover picture: Angewandte Chemie International Edition, 2004, 43, 4537.
Also featured in Chemical and Engineering News, July 12, 2004, 82, 28, 9.
13. Ian Paterson, Robert Britton, Kate Ashton, Henner Knust and Jonathan Stafford. 'Synthesis of antimicrofilament marine macrolides: synthesis and configurational assignment of a C5-C16 degradation fragment of reidispongiolide A.' Proceedings of the National Academy of Sciences, 2004
12. Ian Paterson, Robert Britton, Oscar Delgado and Amy E. Wright. 'Stereochemical determination of dictyostatin, a novel microtubule-stabilising macrolide from the marine sponge Corallistidae sp.' Chemical Communications, 2004
11. Ian Paterson, Kate Ashton, Robert Britton and Henner Knust. 'Toward the Synthesis of Reidispongiolide A: Stereocontrolled Synthesis of the C17-C22 and C23-C35 Degradation Fragments.' Organic Letters, 2003
Doctoral Publications
10. Robert Britton, Edward Piers and Brian O.Patrick. 'Total Synthesis of (±)-13-Methoxy-15-oxozoapatlin, a Rearranged Kaurane Diterpenoid.' Journal of Organic Chemistry, 2004
9. Xiuxian Jiang, Baoguang Zhao, Robert Britton, Lynette Y. Lim, Dan Leong, Jasbinder S. Sanghera, Bin-Bing S. Zhou, Edward Piers, Raymond J. Andersen and Michel Roberge. 'Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide.' Molecular Cancer Therapeutics, 2004
8. Robert Britton, Michel Roberge, Colleen Brown, Rob van Soest and Raymond J. Andersen. 'New Okadaic Acid Analogues From the Marine Sponge Merriamum oxeato andtheir Effect on Mitosis.' Journal of Natural Products, 2003
7. Robert Britton, E. Dilip de Silva, Christina M. Bigg, Lianne M. McHardy, Michel Roberge and Raymond J. Andersen. 'Synthetic Transformations of Eleutherobin Reveal New Features of Its Microtubule-Stabalizing Pharmacophore' Journal of the American Chemical Society, 2001
6. Robert Britton, Michel Roberge, Hans Berisch and Raymond J. Andersen. 'Antimitotic Diterpenoids from Erythropodium caribaeorum: isolation artifacts and putative biosynthetic intermediates.' Tetrahedron Letters, 2001
5. Robert Britton, Jaine H. de Oliveira, Raymond J. Andersen and Roberto Berlinck. 'Granulatimide and 6-Bromogranulatimide: Minor Alkaloids of the Brazilian Ascidian Didemnum Granulatum.' Journal of Natural Products, 2001
4. Edward Piers, Robert Britton and Raymond J. Andersen. 'Improved Synthesis of Isogranulatimide, a G2 Checkpoint Inhibitor. Synthesis of Didemnimide C, Isodidemnimide A, Neodidemnimide A, 17-Methylgranulatimide and Isogranulatimides A-C.' Journal of Organic Chemistry, 2000
3. Roberto Berlinck, Robert Britton, Edward Piers, Raymond J. Andersen, Michel Roberge, Lynette Lim and Rosana Moreira da Rocha. 'Inibidores do Desenvolvimento Celular: Uma Nova Abordagem para o Tratamento de Tumores Sólidos' Estudos Avançados, 1999
2. Roberto Berlinck, Robert Britton, Edward Piers, Lynette Lim, Michele Roberge, Rosana Moreira da Rocha and Raymond J. Andersen. 'Granulatimide and Isogranulatimide, Aromatic Alkaloids with G2 Checkpoint Inhibition Activity Isolated from the Brazilian Ascidian Didemnum Granulatum.' Journal of Organic Chemistry, 1998
1. Michel Roberge, Roberto G. S. Berlinck, Lin Xu, Hilary J. Anderson, Lynette Y. Lim, Darko Curman, Cheri M. Stringer, Stephen H. Friend, Peter Davies, Inez Vincent, Stephen J. Haggarty, Michael T. Kelly, Robert Britton, Edward Piers and Raymond J. Andersen. 'High Throughput Assay for G2 Checkpoint Inhibitors and Identification of the Structurally Novel Compound Isogranulatimide.' Cancer Research, 1998
Patents
2. R. Gries, G. Khaskin, H. Daroogeh, C. Mart, R. Britton, G. Gries; 'Composition of Chemicals for Manipulating the Behaviour of the Pistachio Twig Borer, Kermania Pistaciella (Lepidoptera: Oinophilidae)' PCT Patent Application No. PCT/CA2006/000059. Filed Jan. 6, 2006.
1. O. Delgado, I. Paterson, R. Britton, K. Poullennec, A. Meyer, A. Wright; 'Methods for the synthesis of dictyostatin and derivatives and analogues thereof, stereochemical characterization, novel dictyostatin compounds and uses thereof and synthetic intermediates' Publication date: July 28, 2005. Patent No. WO2005068451.2. R. Andersen, M. Roberge, R. Britton, D. De Silva; 'Antimitotic Eleuthosides' Publication date: December 30, 2004. Patent No.: US2004266700.1. R. Andersen, M. Roberge, S. Jasbinder, D. Leung, R. Berlinck, E. Piers, R. Britton; 'Granulatimide Derivatives for use in Cancer Treatment' Publication date: January 24, 2001. Patent No.: EP1070068 (also published as 'Granulatimide compounds and uses thereof' US6291447)
Books / Reviews
2. S. Chang, S. Halperin, J. Moore, R. Britton. "Chiral Auxiliaries in Drug Synthesis" In Stereoselective Synthesis of Drugs and Natural Products. V. Andrushko & N. Andrushko, Eds. Wiley, 2013
1. Britton, R. 'Natural Compounds as Drugs, Volumes I and II' Edited by Petersen, F.; Amstutz, R. 2009
